COVER STORY This issue:   Tadashi Yanai grew Uniqlo into a global force.  Now he’s out to fix his country. The previous evening’s storm cloouds have cleared to bathe Tokyo in crisp sunshine. Tadashi Yanai, Japan’s richest man and the founder of $73 billion apparel empire Uniqlo, is perusing the art books that line his wood-paneled office, which, like most of his firm’s cavernous headquarters, commands sweeping vistas of the Sumida River….To understand the world we live in, read TIME.

The weight-loss drug explosion has forced a reconsideration of what “healthy” means. It’s unusual for a medication to become a household name; even more uncommon for its branding to become, like Advil, shorthand for an entire class of products; and rarest of all, for it to change not just U.S. medicine, but U.S. cuture, Ozempic has done all three. Approved in 2017 as a Type 2 diabetes medication, Ozempic has largely made its name—and a fortune for its manufacturer, Novo Nordisk—as a weight loss aid….

Peter Paccone, a social-studies teacher in San Marino, Calif., has a new teacher’s aid helping him in the classroom this year. He plans to defer to his helper to explain some simpler topics to his class of high schoolers, like the technical aspects of how a cotton gin worked, in order to free up time for him to discuss more analytical concepts, like the effects of the first Industrial Revolution. His new assistant? ChatGPT. “What I feel that I don’t have to do any longer is…