COVER STORY this issue: Brutal Reality. The vanishing of Jamal Khahoggi threatens to make a global pariah out of Saudi Arabia’s once feted crown prince.  Before the world even learned his age, it could glean that the young man who runs Saudi Arabia takes extraordinary chances with violence. Mohammed Bin Salman, the prince now known by the global shorthand of MBS, was utterly unknown when his father ascended to the Saudi throne in January 2015. It was…  To understand the world we live in, read TIME.

Women across Asia are fighting sexism and assult. It’s been eight years since Seo Ji-Hyun says she was sexually harassed, but it’s still painful to recall. “For a long time, I tourtured myself by blaming myself for everything,” she tell TIME on a cloudy September morning in Seoul’s trendy Apgujeong neighborhood. Seo, a top-level prosecutor in South Korea, alleges that a senior male colleague repeatedly groped her at a funeral in 2010, while the country’s Justice Minister sat nearby…

New discoveries are mobilizing the immune system in the fight against breast cancer. As a pharmacist, Kathy James considers herself well educated about the importance of getting regular cancer screenings. Even though the 55-year-old had no history of cancer in her family, she never skipped her regular mammograms, and she gave herself regular breast exams. So she was dumbfounded when, during one of those self-exams in May 2017, she felt a marble-size lump in her left breast. A visit to…