COVER STORY This issue: Charting his own course in Hollywood. Timothée Chalamet and I are on the run, chasing down Sixth Avenue on a bright September day in search of a place to talk. The restaurant in Greenwich Village where we had planned to meet ended up getting swarmed by NYU students while I was waiting for him, chattering excitedly to one another—“Timothée Chalamet is here!” “Shut up!” “Yeah, he’s right outside!”—so, trying to avoid a deluge of selfie seekers…To understand the world we live in, read TIME.

LGBTQ Koreans are fighting for an end to discrimination against their community. Receiving even the most basic of services can be difficult for Park Edhi, a South Korean woman living in the capital, Seoul. Because official documents do not reflect the fact that Park is transgender, her identity is questioned at every turn. To apply for a credit card “took a very long time,” says Park, who is a coordinator at Dding Dong, the only LGBTQ youth crisis support center in South Korea. “They didn’t think I was me. I remember [the delivery person] came with my card, then said they’d come back tomorrow. So the next day, I smiled and showed my medical records proving I’m taking hormones”…

Dr. Raj Panjabi on preparing for the next pandemic. On Oct. 6, the World Health Organization announced it was recommending a malaria vaccine, the first ever such shot for the mosquito-borne infectious disease that kills hundreds of thousands of people every year. It’s a huge development in the effort to put an end to the oldest pandemic still stalking the planet. But its limitations are real, and offer a view into what we need to do to prepare for the next global disease. Medical breakthroughs on their own can’t defeat malaria—vaccines, tests and treatments don’t deliver themselves. Health workers do. Indeed, Thailand cut its malaria cases by 90% by training a million community health workers over the…